Peritubular Capillary C4d Deposition in Chronic Allograft Dysfunction
نویسندگان
چکیده
منابع مشابه
Thrombotic microangiopathy and peritubular capillary C4d expression in renal allograft biopsies.
BACKGROUND AND OBJECTIVES This study characterizes the pathologic and clinical relationships of thrombotic microangiopathy (TMA) to antibody-mediated rejection (AMR) in renal allograft biopsies. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Consecutive renal allograft biopsies, routinely stained for C4d over a period of 51 months (n=1101), were reviewed. For comparative analysis of histology ...
متن کاملImmunohistochemical evidence of activated lectin pathway in kidney allografts with peritubular capillary C4d deposition.
BACKGROUND Complement 4d (C4d) deposition in the peritubular capillary (PTC) in the kidney allograft is a useful diagnostic marker for humoral rejection. C4d is produced not only by the classical pathway but also by the lectin pathway of the complement activation cascade. We have recently reported the in situ role of the later phase of the complement cascade in renal allografts with C4d deposit...
متن کاملCapillary Deposition of Complement C4d and C3d in Chinese Renal Allograft Biopsies
BACKGROUND C3d is a product of both the classic and the alternative complement cascades; however, few studies have addressed the role of C3d in renal biopsies and its relationship with long-term graft survival rate is not very clear. METHODS 94 patients with biopsy-proven acute rejection episodes were included in the study. We investigated the associations between histological findings, clini...
متن کاملChronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries.
The pathogenesis of chronic renal allograft rejection (CR) remains obscure. The hypothesis that a subset of CR is mediated by antidonor antibody was tested by determining whether C4d is deposited in peritubular capillaries (PTC) and whether it correlates with circulating antidonor antibodies. All cases (from January 1, 1990, to July 31, 1999) that met histologic criteria for CR and had frozen t...
متن کاملComplement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries.
The distinction between acute humoral rejection (AHR) and acute cellular rejection (ACR) in renal allografts is therapeutically important, but pathologically difficult. Since AHR is probably mediated by antibodies to the donor endothelium that activate the classical complement pathway, it was hypothesized that peritubular capillary C4d deposition might distinguish this group. Renal biopsies (n ...
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ژورنال
عنوان ژورنال: Yonsei Medical Journal
سال: 2004
ISSN: 0513-5796
DOI: 10.3349/ymj.2004.45.5.859